Synthesis of 2,5-disubstituted 6-azaindoles from substituted aziridines via intramolecular cyclization.
نویسندگان
چکیده
A new and efficient preparation of pharmacologically and biologically important 2,5-disubstituted 6-azaindoles was achieved from cyclizations of aziridin-2-yl dipropargylic alcohols as adducts of two propargyl groups to ethyl 1-benzylaziridine-2-carboxylate. The sequential cyclizations include pyrrole formation and a novel base-catalyzed intramolecular acetylenic Schmidt reaction.
منابع مشابه
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ورودعنوان ژورنال:
- Organic letters
دوره 14 12 شماره
صفحات -
تاریخ انتشار 2012